VHS had led by one after the third quarter.
Annie Roche scored 17 points, grabbed four rebounds, made four assists and two steals.
The Tanagers fell behind 18-13 after the opening period, led 27-24 at halftime, and then led 40-39 after the third period.
The loss was aided by the Tanagers committing 22 turnovers.
"Our kids did some nice things again tonight," said VHS coach Jamie Parish. "We need to do a better job of rebounding and taking away easy baskets. Offensively, we are still trying to find a rhythm that will give us opportunities to score for all of our players."
VHS saw its record fall to 3-4, while Pipestone upped its mark to 12-1.
VHS hit 7 of 16 three-pointers and made 14 of 18 free throw tries. The Tanagers sank 14 of 38 field goal attempts, while Pipestone was 20 of 39 from the field. Pipestone made 3 of 11 three-point attempts and made 11 of 16 free throw tries.
The Tanagers had several noteworthy individual efforts in defeat.
"Annie Roche played well again offensively," coach Parish said. "Michelle Olson hit some jumpers for us and we are starting to see more balance but it's not where we would like it yet. Our kids are working hard and continuing to get better. Sometimes as coaches we just want things to happen more quickly but we have to remember to be patient."
Individual stats, VHS: Scoring � Annie Roche, 17, Michelle Olson, 10, Alicia Brown, 9, Brittany Bye, 5, Chelsea Gauer, 4, Paige Prosser, 3. Rebounds � Brown, 6, Roche, 4. Assists � Roche, 4, Brown, 3. Steals � Roche, 2.
Individual Stats, Pipestone: Scoring � Steph Kocourek, 15, Faith Tink-lenberg, 13, Paige Pals, 10, Ashley Weatherly, 8, Kelsey Lorenzen, 5, Erica Dar-veaux, 2, Larissa Veldhuizen, 1. Rebounds � Kocourek, 6, Pals, 5, Weatherly, 4. Assists � Pals, 3. Steals � Weatherly, 4.
Team rebounds: VHS � 22, Pipestone � 21. Team fouls: VHS � 15, Pipestone � 18.