VHS had trailed by nine going into the final period.
Annie Roche scored 25 points, made three assists and stole the ball three times. Alisha Brown poured in 15 points, made 11 assists, three steals and grabbed five rebounds.
The Tanagers fell behind 18-17 after the first quarter, trailed 29-27 at halftime, and then trailed 46-37 going into the fourth quarter.
The Tanagers committed only six turnovers while forcing 20.
Harrisburg tried to keep things close from three-point range, hitting 7 of 13 from long distance.
"Handling first game jitters, a fourth quarter comeback and getting a tough win on the road is a pretty good way to start our season," said VHS coach Jamie Parish. "On the whole, we are pretty happy with the way the kids played. At this point we are discussing getting better on a daily basis; we saw some potential for some very good things last night but realize that we are far from a polished team and have several things to work on to achieve our team goals."
VHS improved its record to 1-0, while Harrisburg dropped to 0-2.
VHS sank 11 of 16 free throw tries. The Tanagers connected on 21 of 63 from the field, while Harrisburg was 13 of 47 from the field. The hit 7 of 10 free throw tries.
The Tanagers had several important contributors in the close win.
"Alicia Brown played one of the best games I have ever seen her play," coach Parish said. "She didn't shoot the ball as well as she usually does, but was all over the floor diving for loose balls and getting her hands on so many passes. I really think she showed some maturity from last season in the way she defended last night. "Krista Froke also played a great game; she did her job and took care of a lot of the dirty work for us, getting 11 rebounds and playing great defensively," he added. "Annie Roche had a nice game offensively for us; she handled the ball, dished it off and shot it well from the floor. Alexa Walker provided a spark off the bench coming in causing some turnovers and hitting some open jumpers.
Coach Parish noted that Chelsea Gauer, Rachel Odens and Sara Kjose "also did some great things for us. Chelsea worked hard to make herself into a good defender and did a real nice job covering girls that were bigger than her all night long."
Individual Stats, VHS: Scoring – Annie Roche, 25, Alisha Brown, 15, Alexa Walker, 6, Rachel Odens, 5, Chelsea Gauer, 4, Krista Froke, 3. Rebounds – Froke, 11, Brown, 5. Assists – Roche, 3, Brown, 3. Steals – Brown, 5.
Individual Stats, Harrisburg: Scoring – Alison Bierle, 20, Lindsay Johnson, 14, Mikaela Selcher, 7, Emma Johnson, 6, Renae Christensen, 4, Dani DeMent, 2. Rebounds – L. Johnson, 8, E. Johnson, 4. Assists – Selcher, 3. Steals – Bierle, 2.
Team rebounds: VHS – 26, Harrisburg – 28. Team fouls: VHS – 17, Harrisburg – 15.