VHS had led by one after the third quarter.
The season-opening loss gave VHS a record of 0-1 while Harrisburg moved to 1-0.
Alicia Brown scored 16 points, grabbed eight rebounds, made two assists and four steals.
VHS jumped ahead 15-9 after the first quarter, but was outscored 12-9 in the second period and 18-16 in the third to lead 40-39 going into the final period.
VHS lost the game from the free throw line, making 6 of 14 charity tosses compared with 14 of 29 for Harrisburg.
"The first game out is always an experience," said VHS coach Jamie Parish. "We need to put combinations of kids on the floor and see what type of results we will get. Our staff was happy with our effort; the girls played extremely hard for the entire game. They were all getting after loose balls and running hard. To move forward from this point, our team needs to improve on some very small things. "Communication is not always easy to coach, but all good teams have it. Teams that communicate with each other trust each other. They know that if one person makes a mistake, their teammate will cover up for them," he said. "Taking away an opponent's easy baskets is also important; we need to pressure the ball and keep our opponents from getting second opportunities with offensive rebounds. Our coaches really like the kids we have this year, we like the tools that we have to worth with but coaches and athletes alike still need to figure out how to use those tools to the greatest benefit of our team. We're confident as the season progresses we will show a great deal of improvement."
VHS sank 5 of 18 three-point attempts. The Tanagers sank 21 of 61 field goals, while Harrisburg was 21 of 65 from the field. The Tigers made 2 of 7 three-pointers.
VHS was outrebounded 38-26.
Individual stats, VHS: Scoring – Alicia Brown, 16, Sara Kjose, 11, Alexa Walker, 11, Sierra Allen, 7, Hannah Nehlich-Arobba, 6, Justine Sorensen, 2. Rebounds- Brown, 8, Sierra Allen, 5. Assists – Kjose, 3. Steals – Brown, 4, Walker, 4.
Individual stats, Harrisburg: Scoring – Emma Johnson, 16, Dani DeMent, 12, Lindsay Johnson, 12, Allison Vos, 8, Allison Bierle, 7, Morgan Fischer, 2, Renee Christensen, 1. Rebounds – Bierle, 7, L. Johnson, 7, E. Johnson, 9. Assists – Bierle, 5. Steals – Vos, 4.
Team fouls: VHS – 23, Harrisburg girls – 17.